Histamin Metabolism

Histamin is an important neurotransmitter and serves as a mediator in allergic reactions, inflammation, and gastric secretion. So it can be expected that its metabolism play a key role in cerebral function, cognition in particular, and a variety of biochemical reactions, mostly adverse reactions.

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Histamine is synthesized from histidine an amino acid by histidine decarboxylase (HDC, 142704). While most of the Histamine is degraded by histamine N-methyltransferase (HNMT, 605238) in the central nervous system, the rest of the body metabolizes histamine with an enzyme nicknamed DAO that is called scientifically amiloride-binding protein 1 (ABP1, 104610).