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L1 Mobile ElementThe sequence of a typical L1 Retrotransposon downloaded from NCBI.
LOCUS HSU09116 6539 bp DNA linear PRI 26-OCT-2005
DEFINITION Human retrotransposable L1 element LRE2 from chromosome 1q.
ACCESSION U09116
VERSION U09116.1 GI:483914
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6539)
AUTHORS Holmes,S.E., Dombroski,B.A., Krebs,C.M., Boehm,C.D. and
Kazazian,H.H. Jr.
TITLE A new retrotransposable human L1 element from the LRE2 locus on
chromosome 1q produces a chimaeric insertion
JOURNAL Nat. Genet. 7 (2), 143-148 (1994)
PUBMED 7920631
REFERENCE 2 (bases 1 to 6539)
AUTHORS Holmes,S.E.
TITLE Direct Submission
JOURNAL Submitted (20-APR-1994) Susan E. Holmes, Pediatrics, The Johns
Hopkins University School of Medicine, 600 N. Wolfe Street,
Baltimore, MD 21218, USA
FEATURES Location/Qualifiers
source 1..6539
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q"
mobile_element 1..6539
/mobile_element_type="transposon:LRE2"
5'UTR 1..884
CDS 885..1901
/note="encodes a 40 kDa product"
/codon_start=1
/product="ORF1"
/protein_id="AAB60344.1"
/db_xref="GI:483915"
/translation="MGKKQNRKTGNSKTQSASPPPKERSSSPATEQSWMENDFDELRE
EGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELRE
ECRSLRSRCDQLEERVSAMEDEMNEMKREGKFREKRIKRNEQSLQEIWDYVKRPNLRL
IGVPESDVENGTKLENTLQDIIQENFPNLARQANVQIQEIQRTPQRYSSRRATPRHII
VRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETLQARREWGPIFNILKEKNF
QPRISFPAKLSFISEGERKYFTDKQMLRDFVTTRPTLKELLKEALNMERNNRYQPLQN
HAKM"
CDS 1965..5792
/note="encodes a reverse transcriptase homolog"
/codon_start=1
/product="ORF2"
/protein_id="AAB60345.1"
/db_xref="GI:483916"
/translation="MTGSNSHITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQET
HLMCRDTHRLKIKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKG
SIQQEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSILDRSTRQK
VNKDTQELNSALHQADLIDIYRTLHPKSTEYTFFSAPHHTYSKIDHIVGSKALLSKCK
RTEIITNYLSDHSAIKLELRIKNLTQSRSTTWKLNNLLLNDYWVHNEMKAEIKMFFET
NENKDTTYQNLWDAFKAVCRGKFIALNAYKRKQERSKIDTLTSQLKELEKQEQTHSKA
SRRQEITKIRAELKEIETQKTLQKINESRSWFFERINKIDRPLARLIKKKREKNQIDT
IKNDKGDITTDPTEIQTTIREYYKHLYANKLENLEEMDTFLDTYTLPRLKQEEVESLN
GPITGSEIVAIINSLPTKKSPGPDGFTAEFYQRYKEELVPFLLKLFQSIEKEGILPNS
FYEASIILIPKPGRDTTKKENFRPISLMNIDAKILNKILANRIQQHIKKLIHHDQVGF
IPGMQGWFNIRKSINVIQHINRAKDKNHMIISIDAEKAFDKIQQPFMLKTLNKLGIDG
TYFKIIRAIYDKPTANIILNGQKLEAFPLKTGTRQGCPLSPLLFNIVLEVLARAIRQE
KEIKGIQLGKEEVKLSLFADDMIVYLENPIVSAQNLLKLISNFSKVSGYKINVQKSQA
FLYTNNRQTESQIMGELPFTIASKRIKYLGIQLTRDVKDLFKENYKPLLKEIKEDTNK
WKNIPCSWVGRINIVKMAILPKVIYRFNAIPIKLPMTFFTELEKTTLKFIWNQKRARI
AKSILSQKNKAGGITLPYFKLYYKATVTKTAWYWYQNRDIDQWNRTEPSEIMPHIYNY
LIFDKPEKNKQWGKDSLFNKWCWENWLAICRKLKLDLFLTPYTKINSRWIKDLNVKPK
TIKTLEENLGITIQDIGVGKDFMSKTPKAMATKDKIDKWDLIKLKSFCTAKETTIRVN
RQPTTWEKIFATYSSDKGLISRIYNELKQIYKKKTNNPIKKWAKDMNRHFSKEDIYAA
KKHMKKCSSSLAIREMQIKTTMRYHLTPVRMAIIKKSGNNRCWRGCGEIGTLLHCWWD
CKLVQPLWKSVWRFLRDLELEIPFDPAIPLLGIYPEDYKSCCYKDTCTRMFIAALFTI
AKTWNQPKCPTMIDWIKKMWHIYTMEYYAAIKNDEFISFVGTWMKLETIILSKLSQEQ
KTKHRIFSLIGGN"
variation 2576
/note="LRE2*1 allele"
/replace="t"
variation 5508
/note="LRE2*1 allele"
/replace="a"
variation 5546
/note="LRE2*3 allele"
/replace="a"
3'UTR 5793..6035
polyA_signal 5995..6001
/note="variant signal found within LRE2 3'UTR"
variation 5999..6010
/note="LRE2*1 allele"
/replace=""
misc_feature 6036..6539
/note="most of 3' flank was transcribed along with LRE2"
misc_feature 6036..6524
/note="Unique Sequence Component (USC) was included in
readthrough transcript and forms part of chimeric
dystrophin insertion, GenBank Accession Number U09115"
polyA_signal 6502..6507
/note="variant signal found within 3' flank (USC)"
ORIGIN
1 gaataggaac agctccggtc tacagctccc agcgtgagcg acgcagaaga cggtgatttc
61 tgcatttcca tctgaggtac cgggttcatc tcactaggga gtgccagaca gtgggcgcag
121 gccagtgtgt gtgcgcaccg tgcgcgagcc gaagcagggc gaggcattgc ctcacctggg
181 aagcgcaagg ggtcagggag ttccctttcc gagtcaaaga aaggggtgat ggacgcacct
241 ggaaaatcgg gtcactccca cccgaatatt gcgcttttca gaccggctta agaaacggcg
301 caccacgaga ctatatccca cacctggctc agagggtcct acgcccacgg aatctcgctg
361 attgctagca cagcagtctg agatcaaact gcaaggcggc aacgaggctg ggggaggggc
421 gcccgccatt gcccaggctt gcttaggtaa acaaagcagc cgggaagctc gaactgggtg
481 gagcccacca cagctcaagg aggcctgcct gcctctgtag gctccacctc tgggggcagg
541 gcacagacaa acaaaaaggc agcagtaacc tctgcagact taagtgtccc tgtctgacag
601 ctttgaagag agcagtggtt ctcccagcac gcagctggag atctgagaac gggcagactg
661 cctcctcaag tgggtccctg acccctgacc cccgagcagc ctaactggga ggcacccccc
721 agcaggggca cactgacacc tcacacggca gggtattcca acagacctgc agctgagggt
781 cctgtctgtt agaaggaaaa ctaacaacca gaaaggacat ctacaccgaa aacccatctg
841 tacatcacca tcatcaaaga ccaaaagtag ataaaaccac aaagatgggg aaaaaacaga
901 acagaaaaac tggaaactct aaaacgcaga gcgcctctcc tcctccaaag gaacgcagtt
961 cctcaccagc aacagaacaa agctggatgg agaatgattt tgacgagctg agagaagaag
1021 gcttcagacg atcaaattac tctgagctac gggaggacat tcaaaccaaa ggcaaagaag
1081 ttgaaaactt tgaaaaaaat ttagaagaat gtataactag aataaccaat acagagaagt
1141 gcttaaagga gctgatggag ctgaaaacca aggctcgaga actacgtgaa gaatgcagaa
1201 gcctcaggag ccgatgcgat caactggaag aaagggtatc agcaatggaa gatgaaatga
1261 atgaaatgaa gcgagaaggg aagtttagag aaaaaagaat aaaaagaaat gagcaaagcc
1321 tccaagaaat atgggactat gtgaaaagac caaatctacg tctgattggt gtacctgaaa
1381 gtgatgtgga gaatggaacc aagttggaaa acactctgca ggatattatc caggagaact
1441 tccccaatct agcaaggcag gccaacgttc agattcagga aatacagaga acgccacaaa
1501 gatactcctc gagaagagca actccaagac acataattgt cagattcacc aaagttgaaa
1561 tgaaggaaaa aatgttaagg gcagccagag agaaaggtcg ggttaccctc aaagggaagc
1621 ctatcagact aacagcagat ctctcggcag aaaccctaca agccagaaga gagtgggggc
1681 caatattcaa cattcttaaa gaaaagaatt ttcaacccag aatttcattt ccagccaaac
1741 taagcttcat aagtgaagga gaaagaaaat actttacaga caagcaaatg ctgagagatt
1801 ttgtcaccac caggcctacc ctaaaagagc tcctgaagga agcactaaac atggaaagga
1861 acaaccggta ccagccgctg caaaatcatg ccaaaatgta aagaccatcg agactaggaa
1921 gaaactgcat caactaatga gcaaaatcac cagctaacat cataatgaca ggatcaaatt
1981 cacacataac aatattaact ttaaatataa atggactaaa ttctgcaatt aaaagacaca
2041 gactggcaag ttggataaag agtcaagacc catcagtgtg ctgtattcag gaaacccatc
2101 tcatgtgcag agacacacat aggctcaaaa taaaaggatg gaggaagatc taccaagcaa
2161 atggaaaaca aaaaaaggca ggggttgcaa tcctagtctc tgataaaaca gactttaaac
2221 caacaaagat caaaagagac aaagaaggcc attacataat ggtaaaggga tcaattcaac
2281 aagaggagct aactatccta aatatttatg cacccaatac aggagcaccc agattcataa
2341 agcaagtcct gagtgaccta caaagagact tagactccca cacattaata atgggagact
2401 ttaacacccc actgtcaata ttagacagat caacgagaca gaaagtcaac aaggataccc
2461 aggaattgaa ctcagctctg caccaagcag acctaataga catctacaga actctccacc
2521 ccaaatcaac agaatataca tttttttcag caccacacca cacctattcc aaaatcgacc
2581 acatagttgg aagtaaagct ctcctcagca aatgtaaaag aacagaaatt ataacaaact
2641 atctctcaga ccacagtgca atcaaactag aactcaggat taagaatctc actcaaagcc
2701 gctcaactac atggaaactg aacaacctgc tcctgaatga ctactgggta cataacgaaa
2761 tgaaggcaga aataaagatg ttctttgaaa ccaacgagaa caaagacacc acataccaga
2821 atctctggga cgcattcaaa gcagtgtgta gagggaaatt tatagcacta aatgcctaca
2881 agagaaagca ggaaagatcc aaaattgaca ccctaacatc acaattaaaa gaactagaaa
2941 agcaagagca aacacattca aaagctagca gaaggcaaga aataactaaa atcagagcag
3001 aactgaagga aatagagaca caaaaaaccc ttcaaaaaat caatgaatcc aggagctggt
3061 tttttgaaag gatcaacaaa attgatagac cgctagcaag actaataaag aaaaaaagag
3121 agaagaatca aatagacaca ataaaaaatg ataaagggga tatcaccacc gatcccacag
3181 aaatacaaac taccatcaga gaatactaca aacacctcta cgcaaataaa ctagaaaatc
3241 tagaagaaat ggatacattc ctcgacacat acactctccc aagactaaaa caggaagaag
3301 ttgaatctct gaatggacca ataacaggct ctgaaattgt ggcaataatc aatagtttac
3361 caaccaaaaa gagtccagga ccagatggat tcacagccga attctaccag aggtacaagg
3421 aggaactggt accattcctt ctgaaactat tccaatcaat agaaaaagag ggaatcctcc
3481 ctaactcatt ttatgaggcc agcatcattc tgataccaaa gccgggcaga gacacaacca
3541 aaaaagagaa ttttagacca atatccttga tgaacattga tgcaaaaatc ctcaataaaa
3601 tactggcaaa ccgaatccag cagcacatca aaaagcttat ccaccatgat caagtgggct
3661 tcatccctgg gatgcaaggc tggttcaata tacgcaaatc aataaatgta atccagcata
3721 taaacagagc caaagacaaa aaccacatga ttatctcaat agatgcagaa aaagcctttg
3781 acaaaattca acaacccttc atgctaaaaa ctctcaataa attaggtatt gatgggacgt
3841 atttcaaaat aataagagct atctatgaca aacccacagc caatatcata ctgaatgggc
3901 aaaaactgga agcattccct ttgaaaactg gcacaagaca gggatgccct ctctcaccgc
3961 tcctattcaa catagtgttg gaagttctgg ccagggcaat caggcaggag aaggaaataa
4021 agggtattca attaggaaaa gaggaagtca aattgtccct gtttgcagac gacatgattg
4081 tttatctaga aaaccccatt gtctcagccc aaaatctcct taagctgata agcaacttca
4141 gcaaagtctc aggatacaaa atcaatgtac aaaaatcaca agcattctta tacaccaaca
4201 acagacaaac agagagccaa atcatgggtg aactcccatt cacaattgct tcaaagagga
4261 taaaatacct aggaatccaa cttacaaggg atgtgaagga cctcttcaag gagaactaca
4321 aaccactgct caaggaaata aaagaggaca caaacaaatg gaagaacatt ccatgctcat
4381 gggtaggaag aatcaatatc gtgaaaatgg ccatactgcc caaggtaatt tacagattca
4441 atgccatccc catcaagcta ccaatgactt tcttcacaga attggaaaaa actactttaa
4501 agttcatatg gaaccaaaaa agagcccgca ttgccaagtc aatcctaagc caaaagaaca
4561 aagctggagg catcacacta ccttacttca aactatacta caaggctaca gtaaccaaaa
4621 cagcatggta ctggtaccaa aacagagata tagatcaatg gaacagaaca gagccctcag
4681 aaataatgcc acatatctac aactatctga tctttgacaa acctgagaaa aacaagcaat
4741 ggggaaagga ttccctattt aataaatggt gctgggaaaa ctggctagcc atatgtagaa
4801 agctgaaact ggatctcttc cttacacctt atacaaaaat caattcaaga tggattaaag
4861 atttaaacgt taaacctaaa accataaaaa ccctagaaga aaacctaggc attaccattc
4921 aggacatagg cgtgggcaag gacttcatgt ccaaaacacc aaaagcaatg gcaacaaaag
4981 acaaaattga caaatgggat ctaattaaac taaagagctt ctgcacagca aaagaaacta
5041 ccatcagagt gaacaggcaa cctacaacat gggagaaaat tttcgcaacc tactcatctg
5101 acaaagggct aatatccaga atctacaatg aactcaaaca aatttacaag aaaaaaacaa
5161 acaaccccat caaaaagtgg gcgaaggaca tgaacagaca cttctcaaaa gaagacattt
5221 atgcagccaa aaaacacatg aagaaatgct catcatcact ggccatcaga gaaatgcaaa
5281 tcaaaaccac tatgagatat catctcacac cagttagaat ggcaatcatt aaaaagtcag
5341 gaaacaacag gtgctggaga ggatgcggag aaataggaac acttttacac tgttggtggg
5401 actgtaaact agttcaacca ttgtggaagt cagtgtggcg attcctcagg gatctagaac
5461 tagaaatacc atttgaccca gccatcccat tactgggtat atacccagag gactataaat
5521 catgctgcta taaagacaca tgcactcgta tgtttattgc ggcactattc acaatagcaa
5581 aaacttggaa ccaacccaaa tgtccaacaa tgatagactg gattaagaaa atgtggcaca
5641 tatacaccat ggaatattat gcagccataa aaaatgatga gttcatatcc tttgtaggga
5701 catggatgaa attggaaacc atcattctca gtaaactatc gcaagaacaa aaaaccaaac
5761 accgcatatt ctcactcata ggtgggaatt gaacaatgag atcacatgga cacaggaagg
5821 ggaatatcac actctgggga ctgtggtggg gtcgggggag gggggagggg tagcattggg
5881 agatatacct aatgctagat gacacattag tgggtgcagc gcaccagcat ggcacatgta
5941 tacatatgta actaacctgc acaatgtgca catgtaccct aaaacttaga gtataattaa
6001 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagatca caccactgca ctccagcctg
6061 ggtgtcaaag cgagaccctg tctcaggaaa aaaaaaaaaa aaaaaaaaaa aggcttaatt
6121 gattgaacca gattcgagaa aacagtgcta aattataatt ttctcaatac tgtaaatatt
6181 tttcaatctt cagcttcatt aacttctata attgaaatta tcccaattat tacctgacat
6241 gtactaaaat tccctaaaat ggatcttgag taacattttc acagtacgat aatttttctc
6301 tctgtatata tttatatagt cacatatatg cacatacatt atacaagcat tacttttcta
6361 taactgtaag gtcagaattt gaagttgtgt tttctttatc tttttatttc caatacttgg
6421 catcaagttg atattcatta gaagtaaagg aggaaggaaa tgaataatct tcagatacta
6481 agaacattac acttaaatta ttattaaatc taatttgcat tctcatatat ggcttagct
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