Peto's Rule is the inversion of Peto's Paradox. It is the Rule of Enforced Enslavement applied specifically to the multi-cellularity fauceir.
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Rational
- As Peto observed that the risk of cancer increases with the time of exposure to a cancerogene and the number of cells exposed [Error: Wrong macro arguments: "http://zotero.org/users/438144/items/BW4KDG6C" for macro 'ref' (maybe wrong macro tag syntax?)]
, larger and longer living species should posses better tumor suppression to not dies early of a malignancy.
- As tumor suppression mechanisms can be interpreted as an enslavements mechanism at the organismal level, Petos's rule is just a special case of enforced enslavement.
Examples
- In elephants a copy number expansion of the TP53 gene is responsible for better tumorsuppression [Error: Wrong macro arguments: "http://zotero.org/users/438144/items/K98A2BW2" for macro 'ref' (maybe wrong macro tag syntax?)]
- Obviously mechanisms of tumorsuppression differs among species the same way as species [Error: Wrong macro arguments: "http://zotero.org/users/438144/items/WTWGIKIH" for macro 'ref' (maybe wrong macro tag syntax?)]
also have a different evolutionary history to increase body size [Error: Wrong macro arguments: "http://zotero.org/users/438144/items/XZWWHA4T" for macro 'ref' (maybe wrong macro tag syntax?)]
.
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